Studies by Domingue et al. (1976) describe the recovery of variant and wall-defective bacterial forms from the blood

Studies by Domingue et al. (1976) describe the recovery of variant and wall-defective bacterial forms from the blood of normal as well as diseased humans.

We have first published in 1983 about a group of very small bacteria isolated from peripheral blood under the suggested name “basoplasmas” or “Basoplasma sanguineum”. These very small bacteria had a mean diameter of 0,25µm, some of them had a cell wall, others were cell-wall-deficient bacteria, either L-forms or mycoplasmas (Ruzicka,1983).

Another difference to the usually found bacteria was that they were alkaliphiles. Alkaliphiles are micro-organisms which require alkaline pH > 10 and show a considerable growth at pH of around 10. Alkaliphiles have been isolated mainly from neutral environments, from soil samples of neutral pH, sometimes even from acidic soil samples. However, they should be considered as extremophiles, even though they can be isolated from normal environments because of their alkaliphily. In this connection the most interesting bacterium is the soil bacterium Agrobacterium tumefaciens that grows in soil with pH=12 and infects the roots and stems of dicotyledonous plants resulting in cancerous growth (galls).

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